Research programs

Connecting biology, signals, place, and outcomes.

Our interconnected programs bring computational methods to questions in cardiovascular, cardiometabolic, and aging-related health.

01

Imaging AI & radiomics

Extracting cardiovascular and cardiometabolic phenotypes from CT, CMR, echocardiography, and retinal imaging.

  • Opportunistic phenotyping from routine imaging
  • Segmentation, radiomics, and imaging biomarkers
  • Disease burden and longitudinal risk
02

EHR & longitudinal phenotyping

Connecting diagnoses, laboratory results, medications, and clinical text to understand health over time.

  • Clinical trajectories and dynamic risk modeling
  • Natural language processing and LLM-enabled phenotyping
  • Cohort development and clinical data harmonization
03

Exposome & environmental health

Understanding how air pollution, heat, greenspace, and neighborhood conditions shape cardiometabolic health.

  • Environmental and social exposure linkage
  • Geospatial and neighborhood risk models
  • Disparities, resilience, and place-based prevention
04

ECG AI & biosignals

Learning from ECG images, waveforms, and physiological signals to improve disease detection and prediction.

  • Image- and waveform-based ECG modeling
  • Subclinical disease and cardiovascular outcomes
  • Telemetry and continuous physiological signals
05

Precision prevention

Identifying who may benefit from earlier assessment and more personalized preventive strategies.

  • Personalized cardiovascular risk assessment
  • Imaging-guided prevention
  • Clinical decision support research
06

Outcomes & implementation

Evaluating whether computational approaches can improve clinical decisions, health equity, and care delivery.

  • Real-world evidence and comparative effectiveness
  • Cost-effectiveness and population impact
  • Fairness, external validation, and implementation
Disease areas

A connected view of health.

Research spans cardiovascular disease and its broader cardiometabolic and environmental context.

Atherosclerotic disease

Diabetes

Dementia & brain health

Metabolic liver disease

Adiposity & body composition

Chronic kidney disease

The next question starts here

What could we
see together?

Bring a clinical question, a computational approach, or a new perspective. Explore collaborative research and training with C3PH.