C3PH HOUSTON METHODIST
DeBakey Heart & Vascular Center
Funding / Research support

Funded questions.
Shared progress.

Selected research support involving C3PH investigators and collaborators across institutions. From computational discovery to prevention in the community.

A portfolio of possibilities 08 Selected projects & programs
NIH PCORI
5 R01 awards · 1 RF1 award · 1 center core · 1 PCORI study
01 / Investigator portfolio

Sadeer Al-Kindi

Imaging, artificial intelligence, environmental health, and investigator development.

05 projects
01 NIH / NHLBI R01HL173186 Project period 2024–2028
R01

CT radiomics for heart failure prevention

Developing and validating imaging-based models that use coronary calcium CT scans to identify people at risk for future heart failure.

Project titleRadiomics-based risk prediction of heart failure using CT calcium score exam

C3PH investigator
Sadeer Al-KindiMultiple principal investigator
Principal investigators
Sadeer Al-Kindi · Shuo Li
Recipient institution
Case Western Reserve University
View NIH RePORTER
Latest listed NIH record · FY 2026 $692,323 Reported annual amount
NIH award history 2 records
Annual NIH records for R01HL173186
Fiscal year Award number Reported amount Source
2026 5R01HL173186-02 $692,323 Record
2025 1R01HL173186-01A1 $742,395 Record
02 NIH / NHLBI R01HL184157 Project period 2026–2028
R01

Smarter decisions about ischemia imaging

Combining screening CT, ECG, and clinical information to guide decisions about additional diagnostic imaging for myocardial ischemia.

Project titleDecision support for ischemia imaging based on AI analysis of low-cost/no-cost screening CT and ECG data

C3PH investigator
Sadeer Al-KindiMultiple principal investigator
Principal investigators
Sadeer Al-Kindi · Sanjay Rajagopalan · David L. Wilson
Recipient institution
Case Western Reserve University
View NIH RePORTER
Latest listed NIH record · FY 2026 $1,573,126 Reported annual amount
NIH award history 1 record
Annual NIH records for R01HL184157
Fiscal year Award number Reported amount Source
2026 1R01HL184157-01 $1,573,126 Record
03 NIH / NHLBI R01HL189500 Project period 2026–2030
R01

RICTOR: precision cardio-oncology

Integrating tumor and cardiovascular CT features with clinical and environmental data to study cancer treatment benefit alongside cardiovascular risk.

Project titleRadiomic-based Integrated Cancer Treatment Benefit and Cardiovascular Outcome Risk (RICTOR scale)

C3PH investigator
Sadeer Al-KindiMultiple principal investigator
Principal investigators
Sadeer Al-Kindi · Anant Madabhushi · Gourav Modanwal
Recipient institution
Emory University
View NIH RePORTER
Latest listed NIH record · FY 2026 $788,336 Reported annual amount
NIH award history 1 record
Annual NIH records for R01HL189500
Fiscal year Award number Reported amount Source
2026 1R01HL189500-01A1 $788,336 Record
04 NIH / NINDS RF1NS145403 Project period 2026–2029
RF1

Environment, mechanisms, and brain health

Investigating how environmental exposures relate to Alzheimer’s disease and related dementias through population research, imaging, and mechanistic studies.

Project titleExternal Environmental Determinants of Alzheimers Type Dementias and Mechanisms

C3PH investigator
Sadeer Al-KindiMultiple principal investigator
Principal investigators
Sadeer Al-Kindi · Anant Madabhushi · Andrew A. Pieper · Sanjay Rajagopalan
Recipient institution
Case Western Reserve University
View NIH RePORTER
Latest listed NIH record · FY 2026 $1,884,854 Reported annual amount
NIH award history 1 record
Annual NIH records for RF1NS145403
Fiscal year Award number Reported amount Source
2026 1RF1NS145403-01A1 $1,884,854 Record
05 NIH / NIMHD P50MD017351 Subproject 8207 Project period 2021–2026 Earlier award records
P50

ACHIEVE Investigator Development Core

Supporting early-stage investigators through mentorship, pilot research, and career development in chronic disease prevention and health disparities.

Project titleACHIEVE Investigator Development Core

C3PH investigator
Sadeer Al-KindiAssistant Director, Investigator Development Core
Principal investigators
M. Safwan Badr
Recipient institution
Wayne State University
View NIH RePORTER
Latest listed NIH record · FY 2023 $84,280 Reported annual amount
NIH award history 3 records
Annual NIH records for P50MD017351
Fiscal year Award number Reported amount Source
2023 5P50MD017351-03 $84,280 Record
2022 5P50MD017351-02 $816,896 Record
2021 1P50MD017351-01 $97,780 Record
02 / Investigator portfolio

Khurram Nasir

Atherosclerosis biology, cardiovascular risk, and community-connected prevention.

03 projects
06 NIH / NHLBI R01HL163535 Project period 2023–2027
R01

Understanding dysfunctional HDL

Studying free cholesterol carried by HDL and its relationship with coronary atherosclerosis to improve understanding of cardiovascular risk.

Project titleHuman Atherogenesis with Underlying Dysfunctional HDL-Free Cholesterol

C3PH investigator
Khurram NasirMultiple principal investigator
Principal investigators
Khurram Nasir · Henry J. Pownall
Recipient institution
Houston Methodist Research Institute
View NIH RePORTER
Latest listed NIH record · FY 2026 $733,191 Reported annual amount
NIH award history 4 records
Annual NIH records for R01HL163535
Fiscal year Award number Reported amount Source
2026 5R01HL163535-04 $733,191 Record
2025 5R01HL163535-03 $748,155 Record
2024 5R01HL163535-02 $736,357 Record
2023 1R01HL163535-01A1 $765,547 Record
07 NIH / NHLBI R01HL158976 Project period 2021–2027
R01

Myocardial injury phenotyping in MESA

Classifying myocardial infarction subtypes and nonischemic myocardial injury in MESA to define their risk factors and support more precise prevention.

Project titleContemporary Classification of Myocardial Injury Events in MESA: Defining Distinct Risk Factor Associations with Myocardial Infarction Type 1-5 and Acute Non-Ischemic Myocardial Injury

C3PH investigator
Khurram NasirMultiple principal investigator
Principal investigators
Andrew DeFilippis · Khurram Nasir
Recipient institution
Vanderbilt University Medical Center
View NIH RePORTER
Latest listed NIH record · FY 2025 $861,329 Reported annual amount
NIH award history 5 records
Annual NIH records for R01HL158976
Fiscal year Award number Reported amount Source
2025 5R01HL158976-05 $861,329 Record
2024 5R01HL158976-04 $845,239 Record
2023 5R01HL158976-03 $871,457 Record
2022 5R01HL158976-02 $896,650 Record
2021 1R01HL158976-01 $969,488 Record
08 PCORI PRESSURE CHECK Awarded 2023 · Project end 2029
Multisite study

Pressure Check: prevention in the community

Comparing community-connected care models, telehealth, and community health worker support to improve blood pressure control across four US cities.

Project titleComparing Three Ways To Manage High Blood Pressure Among Adults

C3PH investigator
Khurram NasirHouston co-principal investigator
Principal investigators
Erica Spatz · Rafael Perez-Escamilla
Recipient institution
Yale University
Study sites
Houston Methodist · Yale New Haven Health · Massachusetts General / Brigham · Sentara Health
View PCORI award Meet the study team
PCORI project budget · Full study $19,471,922 Total across study sites
About this portfolio

NIH records are grouped by core award number and, where applicable, subproject. NIH annual amounts describe the listed award or subproject at its recipient institution. The PCORI amount is the full multisite study budget. These figures do not represent C3PH’s allocation. Earlier award records are identified separately.

This selected portfolio includes research led by C3PH investigators with collaborating institutions. NIH information comes from RePORTER; Pressure Check funding and investigator roles are linked to PCORI and the study team. Updated October 22, 2026.

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